It depends on the severity of the condition but usually the patient starts to notice a difference the first night. Then the patient sleeps better or more the first week. That might be misinterpreted as fatigue but it has to do with being more relaxed. The skin color improves within a few days. The energy starts to improve after a week. The drive to do things, the stamina, the interest in life, per se, increases day by day as the weeks go by. In degenerative processes It is very important to incorporate other resources in order to get the most our of the treatment. So we do recommend physical therapy; the best nutrition; friends and family’s commitment to support the patient desire to improve.